Naturally, being responsible of anyone at all, a baby or an adult either as a parent, relative or a guardian requires you to make certain sacrifices for the general well-being of that person. Being in a serious relationship demands more, sometimes the general emotional, mental, physical, financial, social, sexual and even spiritual well being of the person completely depends on you.
However, no matter how demanding or what sacrifices a relationship requires, any healthy relationship driven by sincerity and true love should never require you to sacrifice any of these:
This is were you sprang from, they gave you the life you are currently enjoying. Your parents, uncles, aunties, siblings are your blood. They cared for you when you were still all about poo and nurtured you until you became what you are currently. They tended and fended for your needs, they made sacrifices to see you feed, grow up healthy, educated and responsible. If sacrifices should be made in your relationship, it should never be your family.
Your friends were there with you before the relationship. They hanged out with you, shared your joy and pain, cheered for you and made you smile even before you met your Mr or Mrs sacrifice. Besides why do they want to isolate you from everyone, what do they intend to do with you after successfully isolating you? Your friends are the ones you will still run to for succor after the relationship, do not let them go except you have a valid reason to.
This is your personal ambition, this is all you truly own as a person. Your desires and aspirations are what makes you what you are. Except they are unreasonable or simply unrealistic, why should anyone want you to drop them in the name of relationship? Before them you have been dreaming about your ambitions, after them you still will. Except they have a better idea and wants to help with it, they should not be asking you to sacrifice your dreams, rather they should be helping you realise them.
If you have made certain promises to yourself and to God to keep yourself or your body, you intend to keep it until when you are ready or when you agreed with your creator, by all means please do. Do not break that promise simply because you met someone pleasing to your eyes and they should not be forcing or coercing you to do so either. If you have certain values and moral rules and breaking them will impede your dignity and reputation, never let anyone paint you black. Stand your ground and stay firm, your reward will surely come.
Conclusion: Nothing is absolute in life. However, whenever someone is asking you to make these sacrifices in your relationship, weigh your options and think it through. No one who truly loves you for you will demand these from you. Even if you are going to, it should be by your own will and choice not a prerequisite or demand order for a relationship to continue. They are not the only one in the world, if you have to stand your ground, do so. You will eventually find someone who will accept you for who you are. Never make unreasonable and life changing sacrifices in the name of love or relationship.